Structure elucidation of (+)-amphidinolide a by total synthesis and NMR chemical shift analysis.

@article{Trost2004StructureEO,
  title={Structure elucidation of (+)-amphidinolide a by total synthesis and NMR chemical shift analysis.},
  author={Barry M Trost and Paul E Harrington},
  journal={Journal of the American Chemical Society},
  year={2004},
  volume={126 16},
  pages={5028-9}
}
The structure elucidation of (+)-amphidinolide A, a cytotoxic macrolide, has been accomplished by employing a combination of NMR chemical shift analysis and total synthesis. Using the reported structure as a starting point, a number of diastereomers of amphidinolide A were prepared. The deviations of the chemical shifts of key protons in each isomer… CONTINUE READING