Structure determination of oligomeric alkannin and shikonin derivatives.

  title={Structure determination of oligomeric alkannin and shikonin derivatives.},
  author={Apostolos Spyros and Andreana N. Assimopoulou and Vassilios P. Papageorgiou},
  journal={Biomedical chromatography : BMC},
  volume={19 7},
Monomeric alkannin and shikonin (A/S) are potent pharmaceutical substances with a wide spectrum of biological activity and comprise the active ingredients for several pharmaceutical preparations. Therefore, the determination of the impurities, degradation products or byproducts in alkannin and shikonin samples is of great importance. Oligomeric alkannin and shikonin are formed during biosynthesis of these bioactive secondary metabolites in Boraginaceaous root plants, during tissue culture… CONTINUE READING