Structure determination of LpxA from the lipopolysaccharide-synthesis pathway of Acinetobacter baumannii.

  title={Structure determination of LpxA from the lipopolysaccharide-synthesis pathway of Acinetobacter baumannii.},
  author={John Badger and Barbara Chie-Leon and Cheyenne Logan and V. N. Sridhar and Banumathi Sankaran and Peter H. Zwart and Vicki L. Nienaber},
  journal={Acta crystallographica. Section F, Structural biology and crystallization communications},
  volume={68 Pt 12},
Acinetobacter baumannii is a Gram-negative pathogenic bacterium which is resistant to most currently available antibiotics and that poses a significant health threat to hospital patients. LpxA is a key enzyme in the biosynthetic pathway of the lipopolysaccharides that are components of the bacterial outer membrane. It is a potential target for antibacterial agents that might be used to fight A. baumannii infections. This paper describes the structure determination of the apo form of LpxA in… CONTINUE READING


Publications citing this paper.
Showing 1-2 of 2 extracted citations

Genetic basis of antimicrobial resistance and clonal dynamics of carbapenem-resistant Acinetobacter baumannii sequence type 191 in a Korean hospital.

Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases • 2015
View 3 Excerpts
Highly Influenced


Publications referenced by this paper.
Showing 1-2 of 2 references


H. Jhoti
Am. Chem. Soc. 48, 403–413. Kleywegt, G. J. & Jones, T. A. (1996). Structure, 4, 1395–1400. Lee, B. I. & Suh, S. W. (2003). Proteins, 53, 772–774. Leslie, A. G. W. (2006). Acta Cryst. D62, 48–57. McCoy, A. J., Grosse-Kunstleve, R. W., Adams, P. D., Winn, M. D., Storoni, • 2005

Nature Biotechnol

J. Greer
18, 1105–1108. Otwinowski, Z. & Minor, W. (1997). Methods Enzymol. 276, 307–326. Raetz, C. R. & Roderick, S. L. (1995). Science, 270, 997–1000. Raetz, C. R. & Whitfield, C. (2002). Annu. Rev. Biochem. 71, 635–700. Robins, L. I., Williams, A. H. & Raetz, C. R. (2009). Biochemistry, 48, 6191– • 2000

Similar Papers

Loading similar papers…