Structure-dependent pseudoreceptor intracellular traffic of adamantyl globotriaosyl ceramide mimics.

@article{Saito2012StructuredependentPI,
  title={Structure-dependent pseudoreceptor intracellular traffic of adamantyl globotriaosyl ceramide mimics.},
  author={Mitsumasa Saito and Murugespillai Mylvaganum and Patty Tam and Anton Novak and Beth A Binnington and Clifford Lingwood},
  journal={The Journal of biological chemistry},
  year={2012},
  volume={287 20},
  pages={16073-87}
}
The verotoxin (VT) (Shiga toxin) receptor globotriaosyl ceramide (Gb(3)), mediates VT1/VT2 retrograde transport to the endoplasmic reticulum (ER) for cytosolic A subunit access to inhibit protein synthesis. Adamantyl Gb(3) is an amphipathic competitive inhibitor of VT1/VT2 Gb(3) binding. However, Gb(3)-negative VT-resistant CHO/Jurkat cells incorporate adaGb(3) to become VT1/VT2-sensitive. CarboxyadaGb(3), urea-adaGb(3), and hydroxyethyl adaGb(3), preferentially bound by VT2, also mediate VT1… CONTINUE READING
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