Structure characterisation of urinary metabolites of the cannabimimetic JWH-018 using chemically synthesised reference material for the support of LC-MS/MS-based drug testing

@article{Beuck2011StructureCO,
  title={Structure characterisation of urinary metabolites of the cannabimimetic JWH-018 using chemically synthesised reference material for the support of LC-MS/MS-based drug testing},
  author={S. Beuck and I. M{\"o}ller and A. Thomas and A. Klose and N. Schl{\"o}rer and W. Schänzer and M. Thevis},
  journal={Analytical and Bioanalytical Chemistry},
  year={2011},
  volume={401},
  pages={493-505}
}
AbstractAs recently reported, the synthetic cannabinoid JWH-018 is the subject of extensive phase I and II metabolic reactions in vivo. Since these studies were based on LC-MS/MS and/or GC-MS identification and characterisation of analytes, the explicit structural assignment of the metabolites was only of preliminary nature, if possible at all. Here, we report the chemical synthesis of five potential in vivo metabolites of JWH-018 derivatives featuring an alkylcarboxy (M1), a terminal… Expand
67 Citations
Characterization of in vitro metabolites of JWH-018, JWH-073 and their 4-methyl derivatives, markers of the abuse of these synthetic cannabinoids.
  • V. Gambaro, S. Arnoldi, +7 authors E. Valoti
  • Chemistry, Medicine
  • Journal of chromatography. B, Analytical technologies in the biomedical and life sciences
  • 2014
  • 16
Detection and tentative identification of urinary phase I metabolites of phenylacetylindole cannabimimetics JWH-203 and JWH-251, by GC-MS and LC-MS/MS.
  • 24
Conjugation of Synthetic Cannabinoids JWH-018 and JWH-073, Metabolites by Human UDP-Glucuronosyltransferases
  • 70
  • PDF
In vivo and in vitro metabolism of the synthetic cannabinoid JWH-200.
  • 40
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 13 REFERENCES
In vitro phase I metabolism of the synthetic cannabimimetic JWH-018
  • 131
Detection of JWH-018 metabolites in smoking mixture post-administration urine.
  • 218
Sensitive and rapid quantification of the cannabinoid receptor agonist naphthalen-1-yl-(1-pentylindol-3-yl)methanone (JWH-018) in human serum by liquid chromatography-tandem mass spectrometry.
  • 152
Screening for the synthetic cannabinoid JWH-018 and its major metabolites in human doping controls.
  • 121
Unusual mass spectrometric dissociation pathway of protonated isoquinoline-3-carboxamides due to multiple reversible water adduct formation in the gas phase
  • 36
  • PDF
Screening for unknown synthetic steroids in human urine by liquid chromatography-tandem mass spectrometry.
  • 124
Matrix effect in bio-analysis of illicit drugs with LC-MS/MS: Influence of ionization type, sample preparation, and biofluid
  • 542
  • PDF
Strategies for the assessment of matrix effect in quantitative bioanalytical methods based on HPLC-MS/MS.
  • 3,824
...
1
2
...