• DOI:10.1007/s00216-011-4931-5
Corpus ID: 33433526

Structure characterisation of urinary metabolites of the cannabimimetic JWH-018 using chemically synthesised reference material for the support of LC-MS/MS-based drug testing

@article{Beuck2011StructureCO,
  title={Structure characterisation of urinary metabolites of the cannabimimetic JWH-018 using chemically synthesised reference material for the support of LC-MS/MS-based drug testing},
  author={S. Beuck and I. M{\"o}ller and A. Thomas and A. Klose and N. Schl{\"o}rer and W. Schänzer and M. Thevis},
  journal={Analytical and Bioanalytical Chemistry},
  year={2011},
  volume={401},
  pages={493-505}
}

• S. Beuck, I. Möller, +4 authors M. Thevis
• Published 2011
• Chemistry, Medicine
• Analytical and Bioanalytical Chemistry

AbstractAs recently reported, the synthetic cannabinoid JWH-018 is the subject of extensive phase I and II metabolic reactions in vivo. Since these studies were based on LC-MS/MS and/or GC-MS identification and characterisation of analytes, the explicit structural assignment of the metabolites was only of preliminary nature, if possible at all. Here, we report the chemical synthesis of five potential in vivo metabolites of JWH-018 derivatives featuring an alkylcarboxy (M1), a terminal… Expand

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