Structure-based thresholds of toxicological concern (TTC): guidance for application to substances present at low levels in the diet.

@article{Kroes2004StructurebasedTO,
  title={Structure-based thresholds of toxicological concern (TTC): guidance for application to substances present at low levels in the diet.},
  author={Robert Kroes and Andrew Gordon Renwick and Michael T. Cheeseman and Juergen Kleiner and Inge Mangelsdorf and Aldert H. Piersma and Beno{\^i}t Schilter and Henk Van Loveren and F van Schothorst and Josephus G Vos and Gunna W{\"u}rtzen},
  journal={Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association},
  year={2004},
  volume={42 1},
  pages={
          65-83
        }
}
The threshold of toxicological concern (TTC) is a pragmatic risk assessment tool that is based on the principle of establishing a human exposure threshold value for all chemicals, below which there is a very low probability of an appreciable risk to human health. The concept that there are levels of exposure that do not cause adverse effects is inherent in setting acceptable daily intakes (ADIs) for chemicals with known toxicological profiles. The TTC principle extends this concept by proposing… CONTINUE READING

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