Structure-based rational design of peptide inhibitors to disrupt the recognition and interaction between hepatitis B virus large envelope protein and human hepatocyte receptor γ2-adaptin


The virion escaping of hepatitis B virus from human hepatocyte is mediated by the recognition and interaction of viral large envelope protein with human hepatocyte receptor γ2-adaptin. In this work, a structure-based rational strategy was described to design peptide inhibitors serving as the interaction disruptors between the preS1 domain of hepatitis B… (More)
DOI: 10.1007/s00044-017-1981-z


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