Structure-based mechanistic insights into DNMT1-mediated maintenance DNA methylation.

  title={Structure-based mechanistic insights into DNMT1-mediated maintenance DNA methylation.},
  author={Jikui Song and Marianna Teplova and Satoko Ishibe-Murakami and Dinshaw J. Patel},
  volume={335 6069},
DNMT1, the major maintenance DNA methyltransferase in animals, helps to regulate gene expression, genome imprinting, and X-chromosome inactivation. We report on the crystal structure of a productive covalent mouse DNMT1(731-1602)-DNA complex containing a central hemimethylated CpG site. The methyl group of methylcytosine is positioned within a shallow hydrophobic concave surface, whereas the cytosine on the target strand is looped out and covalently anchored within the catalytic pocket. The DNA… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 5 times over the past 90 days. VIEW TWEETS

From This Paper

Topics from this paper.
71 Citations
25 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 71 extracted citations


Publications referenced by this paper.
Showing 1-10 of 25 references

Structural insight into maintenance methylation by mouse DNA methyltransferase 1 (Dnmt1)

  • K. Takeshita
  • Proc. Natl. Acad. Sci. U.S.A
  • 2011

Provocative insights from epigenomics

  • M. M. Suzuki, A. Bird, DNA methylation landscapes
  • Nat. Rev. Genet. 9, 465
  • 2008

A . J . McCoy et al . , Phaser crystallographic software

  • K. Cowtan Emsley
  • J . Appl . Crystallogr .
  • 2007

Similar Papers

Loading similar papers…