Structure-based mechanism of ligand binding for periplasmic solute-binding protein of the Bug family.

@article{Herrou2007StructurebasedMO,
  title={Structure-based mechanism of ligand binding for periplasmic solute-binding protein of the Bug family.},
  author={Julien Herrou and Coralie Bompard and Rudy Antoine and Anne Laure Leroy and Prakash Rucktooa and David Hot and Isabelle Huvent and Camille Locht and Vincent Villeret and Françoise Jacob-Dubuisson},
  journal={Journal of molecular biology},
  year={2007},
  volume={373 4},
  pages={954-64}
}
Bug proteins form a large family of periplasmic solute-binding proteins well represented in beta-proteobacteria. They adopt a characteristic Venus flytrap fold with two globular domains bisected by a ligand-binding cleft. The structures of two liganded Bug proteins have revealed that the family is specific for carboxylated solutes, with a characteristic mode of binding involving two highly conserved beta strand-beta turn-alpha helix motifs originating from each domain. These two motifs form… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-6 of 6 extracted citations

Similar Papers

Loading similar papers…