Structure-based insights into the catalytic power and conformational dexterity of peroxiredoxins.

@article{Hall2011StructurebasedII,
  title={Structure-based insights into the catalytic power and conformational dexterity of peroxiredoxins.},
  author={Andrea R Hall and Kimberly J. Nelson and Leslie B. Poole and P. Andrew Karplus},
  journal={Antioxidants & redox signaling},
  year={2011},
  volume={15 3},
  pages={795-815}
}
Peroxiredoxins (Prxs), some of nature's dominant peroxidases, use a conserved Cys residue to reduce peroxides. They are highly expressed in organisms from all kingdoms, and in eukaryotes they participate in hydrogen peroxide signaling. Seventy-two Prx structures have been determined that cover much of the diversity of the family. We review here the current knowledge and show that Prxs can be effectively classified by a structural/evolutionary organization into six subfamilies followed by… CONTINUE READING

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Peroxiredoxins ( Prxs ) , some of nature 's dominant peroxidases , use a conserved Cys residue to reduce peroxides .
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