Structure-based identification and clustering of protein families and superfamilies

  title={Structure-based identification and clustering of protein families and superfamilies},
  author={Stephen D. Rufino and Tom L. Blundell},
  journal={Journal of computer-aided molecular design},
  volume={8 1},
We describe an approach to protein structure comparison designed to detect distantly related proteins of similar fold, where the procedure must be sufficiently flexible to take into account the elasticity of protein folds without losing specificity. Protein structures are represented as a series of secondary structure elements, where for each element a local environment describes its relations with the elements that surround it. Secondary structures are then aligned by comparing their features… CONTINUE READING
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