Structure-based gene targeting discovery of sphaerimicin, a bacterial translocase I inhibitor.


Rise and shine: Using a gene-targeting approach aimed at identifying potential L-threonine:uridine-5'-transaldolases that catalyze the formation of (5'S,6'S)-C-glycyluridine, a new bacterial translocase I inhibitor was discovered from an actinomycete following fermentation optimization. 
DOI: 10.1002/anie.201305546


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