Structure-based fragment shuffling of two fungal phytases for combination of desirable properties.

Abstract

Aspergillus niger NRRL 3135 phytase (Anp) and Aspergillus fumigatus ATCC 13073 phytase (Afp) are quite different but mutually complementary in many properties. A semi-rational protein engineering strategy based on 3D structure and sequence alignment was used to take advantage of the desirable characteristics of both enzymes. Each phytase was divided into… (More)
DOI: 10.1016/j.jbiotec.2008.08.011

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