Structure-based evaluation of in silico predictions of protein-protein interactions using Comparative Docking

@article{Cockell2007StructurebasedEO,
  title={Structure-based evaluation of in silico predictions of protein-protein interactions using Comparative Docking},
  author={Simon J. Cockell and Baldomero Oliva and Richard M. Jackson},
  journal={Bioinformatics},
  year={2007},
  volume={23 5},
  pages={573-81}
}
MOTIVATION Due to the limitations in experimental methods for determining binary interactions and structure determination of protein complexes, the need exists for computational models to fill the increasing gap between genome sequence information and protein annotation. Here we describe a novel method that uses structural models to reduce a large number of in silico predictions to a high confidence subset that is amenable to experimental validation. RESULTS A two-stage evaluation procedure… CONTINUE READING
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