Structure-based drug discovery of ApoE4 inhibitors from the plant compounds

@article{Singh2011StructurebasedDD,
  title={Structure-based drug discovery of ApoE4 inhibitors from the plant compounds},
  author={Kh. Dhanachandra Singh and Muthusamy Karthikeyan and Palani Kirubakaran and Velusamy Sathya and Selvaraman Nagamani},
  journal={Medicinal Chemistry Research},
  year={2011},
  volume={21},
  pages={825-833}
}
Apolipoprotein E4 (ApoE4) is a potential target for developing new therapeutics for Alzheimer’s disease (AD). Till now there is no drug available to inhibit this protein and cholinesterase inhibitor was given for almost all the AD patients. In this study, we have approached to identify the potential ApoE4 inhibitor from the plant compounds. Rigid docking study was performed for 18 plant compounds and 11 cholinesterase inhibitors. Based on the docking score, binding energy and number of hydrogen… CONTINUE READING

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