Structure-based drug design of non-nucleoside inhibitors for wild-type and drug-resistant HIV reverse transcriptase.

  title={Structure-based drug design of non-nucleoside inhibitors for wild-type and drug-resistant HIV reverse transcriptase.},
  author={C. Mao and E. Sudbeck and T. Venkatachalam and F. Uckun},
  journal={Biochemical pharmacology},
  volume={60 9},
  • C. Mao, E. Sudbeck, +1 author F. Uckun
  • Published 2000
  • Medicine, Chemistry
  • Biochemical pharmacology
  • The generation of anti-HIV agents using structure-based drug design methods has yielded a number of promising non-nucleoside inhibitors (NNIs) of HIV reverse transcriptase (RT). Recent successes in identifying potent NNIs are reviewed with an emphasis on the recent trend of utilizing a computer model of HIV RT to identify space in the NNI binding pocket that can be exploited by carefully chosen functional groups predicted to interact favorably with binding pocket residues. The NNI binding… CONTINUE READING
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