Structure-based drug design and optimization of mannoside bacterial FimH antagonists.

Abstract

FimH-mediated cellular adhesion to mannosylated proteins is critical in the ability of uropathogenic E. coli (UPEC) to colonize and invade the bladder epithelium during urinary tract infection. We describe the discovery and optimization of potent small-molecule FimH bacterial adhesion antagonists based on alpha-d-mannose 1-position anomeric glycosides using… (More)
DOI: 10.1021/jm100438s

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