Structure-based discovery of inhibitors of microsomal prostaglandin E2 synthase-1, 5-lipoxygenase and 5-lipoxygenase-activating protein: promising hits for the development of new anti-inflammatory agents.

Abstract

Microsomal prostaglandin E(2) synthase (mPGES)-1 catalyzes the transformation of PGH(2) to PGE(2) that is involved in several pathologies like fever, pain, and inflammatory disorders. To identify novel mPGES-1 inhibitors, we used in silico screening to rapidly direct the synthesis, based on the copper-catalyzed 3 + 2 Huisgen's reaction (click chemistry), of… (More)
DOI: 10.1021/jm101238d

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@article{Simone2011StructurebasedDO, title={Structure-based discovery of inhibitors of microsomal prostaglandin E2 synthase-1, 5-lipoxygenase and 5-lipoxygenase-activating protein: promising hits for the development of new anti-inflammatory agents.}, author={Rosa De Simone and Maria G Chini and Ines Bruno and Raffaele Riccio and Daniela M{\"{u}ller and Oliver Werz and Giuseppe Bifulco}, journal={Journal of medicinal chemistry}, year={2011}, volume={54 6}, pages={1565-75} }