Structure-based discovery of antagonists of nuclear receptor LRH-1.

  title={Structure-based discovery of antagonists of nuclear receptor LRH-1.},
  author={Cindy Benod and Jens Carlsson and Rubatharshini Uthayaruban and Peter Hwang and John J. Irwin and Allison K. Doak and Brian K. Shoichet and Elena P. Sablin and Robert Fletterick},
  journal={The Journal of biological chemistry},
  volume={288 27},
Liver receptor homolog 1 (nuclear receptor LRH-1, NR5A2) is an essential regulator of gene transcription, critical for maintenance of cell pluripotency in early development and imperative for the proper functions of the liver, pancreas, and intestines during the adult life. Although physiological hormones of LRH-1 have not yet been identified, crystallographic and biochemical studies demonstrated that LRH-1 could bind regulatory ligands and suggested phosphatidylinositols as potential hormone… CONTINUE READING
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A nuclear receptor dependent phosphatidylcholine pathway with antidiabetic effects

  • J. M. Lee, Y. K. Lee, +5 authors D. D. andMoore
  • Nature 474,
  • 2011
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