Structure-based design of artificial metalloenzymes and beyond

  title={Structure-based design of artificial metalloenzymes and beyond},
  author={Max Tillmann Heinisch},
Optically active molecules play a fundamental role in the functions of live. The enantioselective synthesis of chiral building blocks is crucial for the production of high value compounds such as pharmaceuticals or pesticides. Besides homogenous transition metal and enzymatic catalysts, artificial metalloenzymes - that consist of metal cofactors anchored within protein scaffolds - have been developed in the past decade to access optically pure compounds. The creation and optimization of these… CONTINUE READING