Structure-based design of a thiazolidinedione which targets the mitochondrial protein mitoNEET.


Several PPAR-gamma agonists containing a thiazolidinedione moiety (referred to as glitazones) have been proposed to be neuroprotective and appear to alter mitochondrial function. Recently, a search for mitochondrial proteins that bind pioglitazone identified a novel protein, mitoNEET, which was later shown to regulate the oxidative capacity of the… (More)
DOI: 10.1016/j.bmcl.2009.12.088

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