Structure-based design and synthesis of novel macrocyclic pyrazolo[1,5-a] [1,3,5]triazine compounds as potent inhibitors of protein kinase CK2 and their anticancer activities.

@article{Nie2008StructurebasedDA,
  title={Structure-based design and synthesis of novel macrocyclic pyrazolo[1,5-a] [1,3,5]triazine compounds as potent inhibitors of protein kinase CK2 and their anticancer activities.},
  author={Zhe Nie and Carin L Perretta and Philip Erickson and Stephen A. Margosiak and Jia Lu and April Averill and Robert J. Almassy and Shaosong Chu},
  journal={Bioorganic & medicinal chemistry letters},
  year={2008},
  volume={18 2},
  pages={619-23}
}
A series of macrocyclic derivatives has been designed and synthesized based on the X-ray co-crystal structures of pyrazolo[1,5-a] [1,3,5]triazines with corn CK2 (cCK2) protein. Bioassays demonstrated that these macrocyclic pyrazolo[1,5-a] [1,3,5]triazine compounds are potent CK2 inhibitors with K(i) around 1.0 nM and strongly inhibit cancer cell growth with IC(50) as low as approximately 100 nM.