Structure-based design, synthesis, and study of potent inhibitors of beta-ketoacyl-acyl carrier protein synthase III as potential antimicrobial agents.

@article{Nie2005StructurebasedDS,
  title={Structure-based design, synthesis, and study of potent inhibitors of beta-ketoacyl-acyl carrier protein synthase III as potential antimicrobial agents.},
  author={Zhe Nie and Carin L Perretta and Jia Lu and Ying Su and Stephen A. Margosiak and Ketan S. Gajiwala and Joseph Cortez and Victor S. Nikulin and Kraig M Yager and Krzysztof Appelt and Shaosong Chu},
  journal={Journal of medicinal chemistry},
  year={2005},
  volume={48 5},
  pages={1596-609}
}
Fatty acid biosynthesis is essential for bacterial survival. Components of this biosynthetic pathway have been identified as attractive targets for the development of new antibacterial agents. FabH, beta-ketoacyl-ACP synthase III, is a particularly attractive target, since it is central to the initiation of fatty acid biosynthesis and is highly conserved among Gram-positive and -negative bacteria. Small molecules that inhibit FabH enzymatic activity have the potential to be candidates within a… CONTINUE READING

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