Structure-based calculation of the equilibrium folding pathway of proteins. Correlation with hydrogen exchange protection factors.

@article{Hilser1996StructurebasedCO,
  title={Structure-based calculation of the equilibrium folding pathway of proteins. Correlation with hydrogen exchange protection factors.},
  author={Vincent J. Hilser and Ernesto Freire},
  journal={Journal of molecular biology},
  year={1996},
  volume={262 5},
  pages={756-72}
}
A new statistical thermodynamic formalism has been developed in order to describe the equilibrium folding pathway of proteins. The resulting formalism allows calculation of the probabilities that individual amino acid residues will be in a native or native-like conformation for any given degree of folding of the protein molecule. The residue probabilities are defined by the probability distribution of conformational states and can be used to calculate experimental quantities like native-state… CONTINUE READING

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