Structure-based assessment of missense mutations in human BRCA1: implications for breast and ovarian cancer predisposition.

@article{Mirkovic2004StructurebasedAO,
  title={Structure-based assessment of missense mutations in human BRCA1: implications for breast and ovarian cancer predisposition.},
  author={Nebojsa Mirkovic and Marc A. Mart{\'i}-Renom and Barbara L. Weber and Andrej Sali and Alvaro N. A. Monteiro},
  journal={Cancer research},
  year={2004},
  volume={64 11},
  pages={3790-7}
}
The BRCA1 gene from individuals at risk of breast and ovarian cancers can be screened for the presence of mutations. However, the cancer association of most alleles carrying missense mutations is unknown, thus creating significant problems for genetic counseling. To increase our ability to identify cancer-associated mutations in BRCA1, we set out to use the principles of protein three-dimensional structure as well as the correlation between the cancer-associated mutations and those that abolish… CONTINUE READING