Structure based Pharmacophore modeling, Virtual screening and Molecular Docking of Potential Phytochemicals against HSP70 -

@inproceedings{Khong2017StructureBP,
  title={Structure based Pharmacophore modeling, Virtual screening and Molecular Docking of Potential Phytochemicals against HSP70 -},
  author={Heng Yen Khong and Nyotia Nyokat and Clifford Junaidi Kutoi and Ahmad Sazali Hamzah and Isabel Fong Lim},
  year={2017}
}
Heat shock protein 70(HSP 70) is a potential anticancer target as it influences many signaling pathways. Structure based pharmacophore modeling was performed , followed by virtual screening from a library of diverse Phytochemicals to identify the potential inhibitors of HSP70, in specific ,to the substrate binding domain .Further validation of the hit compounds was done by Molecular docking and ADMET analysis in Discovery studio V4.0. Pharmacophore modeling resulted in the generation of 5… CONTINUE READING