Structure-associated Functional Control of TX-1877 Series by Glyco-conjugation

@article{Ohkura2018StructureassociatedFC,
  title={Structure-associated Functional Control of TX-1877 Series by Glyco-conjugation},
  author={K. Ohkura and Yuki Kawaguchi and Yohei Tatematsu and A. Tabata and Y. Uto and H. Hori},
  journal={AntiCancer Research},
  year={2018},
  volume={38},
  pages={4241 - 4245}
}
Background/Aim: Sugar molecules are often used as a tool to structurally modify chemical compounds. The features of synthesized sugar-conjugated TX-1877 derivatives were herein examined. Materials and Methods: The molecular stabilities (reactivity) and hydrophobicities of sugar (e.g., monosaccharide and tetra-O-acetylated monosaccharide)-conjugated TXs were analyzed using a molecular simulation (e.g. molecular mechanics (MM) and molecular orbital (MO) analysis). Results: The hydrophobicities of… Expand
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