Structure-assisted design of nonpeptide human immunodeficiency virus-1 protease inhibitors.

@article{Rose1994StructureassistedDO,
  title={Structure-assisted design of nonpeptide human immunodeficiency virus-1 protease inhibitors.},
  author={Janet R. Rose and Charles S. Craik},
  journal={American journal of respiratory and critical care medicine},
  year={1994},
  volume={150 6 Pt 2},
  pages={S176-82}
}
The discovery of therapeutic agents has, in the past, started primarily with random screening efforts. These screens, although effective, are time-consuming and expensive. Attempts are now being made to design more efficient methods of screening that take into account available information about the three-dimensional structure of a target receptor or enzyme… CONTINUE READING