Structure-antioxidant activity relationships of flavonoids and phenolic acids.

@article{Riceevans1996StructureantioxidantAR,
  title={Structure-antioxidant activity relationships of flavonoids and phenolic acids.},
  author={C. Rice-evans and Nicholas J. Miller and George Paganga},
  journal={Free radical biology \& medicine},
  year={1996},
  volume={20 7},
  pages={
          933-56
        }
}
The recent explosion of interest in the bioactivity of the flavonoids of higher plants is due, at least in part, to the potential health benefits of these polyphenolic components of major dietary constituents. This review article discusses the biological properties of the flavonoids and focuses on the relationship between their antioxidant activity, as hydrogen donating free radical scavengers, and their chemical structures. This culminates in a proposed hierarchy of antioxidant activity in the… Expand
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Evidence is obtained of a clear difference among the pKa, the complexation properties, and the lipophilicity of the flavonoids studied, which can partially explain their distinct antioxidant activity. Expand
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It is now possible to establish the antioxidant activities of plant-derived flavonoids in the aqueous and lipophilic phases, and to assess the extent to which the total antioxidant potentials of wine and tea can be accounted for by the activities of individual polyphenols. Expand
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Publisher Summary Studies described in this chapter indicate the multiple properties that flavonoids possess for scavenging reactive oxygen species and reactive nitrogen species. In considerations ofExpand
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Flavonoids have the ability to sequester free radicals are natural antioxidants derived from plants and commonly found in foods and beverages. Flavonoids have many potential beneficial properties.Expand
Flavonoid antioxidants: chemistry, metabolism and structure-activity relationships.
TLDR
The diversity and multiple mechanisms of flavonoid action, together with the numerous methods of initiation, detection and measurement of oxidative processes in vitro and in vivo offer plausible explanations for existing discrepancies in structure-activity relationships. Expand
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