Structure-antimicrobial activity relationship and action mechanism of dimeric quaternary ammonium amphiphiles

  title={Structure-antimicrobial activity relationship and action mechanism of dimeric quaternary ammonium amphiphiles},
  author={Xiao Fang Zhao and Ya Hong Li and Hao Yuan},
  booktitle={ICME 2015},
The antibacterial activity of the five dimeric quaternary ammonium amphiphiles against Escherichia coli were evaluated by determining the minimum inhibitory concentration (MIC) and compared with one monomeric quaternary ammonium amphiphile. The antibacterial activity of dimeric amphiphiles is superior to the corresponding monomeric amphiphile. The action mechanism was investigated by measuring the activity of β-galactosidase from E. coli and scanning electron microscopy (SEM) imaging of E. coli… CONTINUE READING


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