Structure-antifungal activity relationship of His-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2 and analogues.

@article{Masman2008StructureantifungalAR,
  title={Structure-antifungal activity relationship of His-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2 and analogues.},
  author={Marcelo Fabricio Masman and Csaba Somlai and Francisco M. Garibotto and Ana M Rodr{\'i}guez and Agustina I de la Iglesia and Susana Zacchino and Botond Penke and Ricardo D. Enriz},
  journal={Bioorganic & medicinal chemistry},
  year={2008},
  volume={16 8},
  pages={4347-58}
}
The synthesis, in vitro evaluation and conformational study of His-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH(2) and analogues acting as antifungal agents are reported. Among them, His-Phe-Lys-Trp-Gly-Arg-Phe-Val-NH(2) exhibited a moderate but significant antifungal activity against Cryptococcus neoformans, Candida albicans and Candida tropicalis. A theoretical study… CONTINUE READING