Structure and variation of human ribosomal DNA: molecular analysis of cloned fragments.

  title={Structure and variation of human ribosomal DNA: molecular analysis of cloned fragments.},
  author={Jeanne M. Erickson and C L Rushford and D J Dorney and Golder N. Wilson and Roy D. Schmickel},
  volume={16 1-3},
Eco-RI-A fragments of the human ribosomal RNA gene family from two types of tissue and three individuals were cloned in lambda vectors and compared by restriction enzyme digestion and electron microscopy. The EcoRI fragment A contains (i) 0.2 kb of the 3' end of the 18S rDNA, (ii) 2.5 kb of internal transcribed spacer and the 5.8S rDNA, and (iii) 4.6 kb of the 28S rDNA gene. All of the six cloned rDNA fragments isolated are identical by these analyses. Moreover, all contain a HincII site that… CONTINUE READING
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