• DOI:10.1038/298329A0
Corpus ID: 11904305

Structure and variation of human α1–antitrypsin

@article{Carrell1982StructureAV,
  title={Structure and variation of human α1–antitrypsin},
  author={R. Carrell and J. Jeppsson and C. Laurell and S. Brennan and M. Owen and L. Vaughan and D. Boswell},
  journal={Nature},
  year={1982},
  volume={298},
  pages={329-334}
}

R. Carrell, J. Jeppsson, +4 authors D. Boswell

Published 1982

Biology, Medicine

Nature

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ncbi.nlm.nih.gov

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The sequence of α1–antitrypsin is in keeping with its role as a tissue scavenger of leukocyte elastase. Two abnormal variants commonly present in Europeans cause a deficiency that predisposes them to a progressive loss of lung elasticity. The nature of the reactive centre helps explain why cigarette smoking greatly accelerates the onset and severity of this degenerative process to give the disease emphysema.