Structure and transcription regulation of the human insulin-like growth factor binding protein 4 gene (IGFBP4).

@article{Zazzi1998StructureAT,
  title={Structure and transcription regulation of the human insulin-like growth factor binding protein 4 gene (IGFBP4).},
  author={Henric Zazzi and Andrej Nikoshkov and Kerstin Hall and Holger Luthman},
  journal={Genomics},
  year={1998},
  volume={49 3},
  pages={401-10}
}
Insulin-like growth factor binding protein 4 (IGFBP-4) is locally produced by normal human bone cells and acts as a potent inhibitor of IGF action in this tissue. PTH and a cAMP analog increase the expression of IGFBP4 mRNA in human osteoblast cells. We now show that the human IGFBP4 gene is contained within 15.3 kb with the transcription initiation site located 28 bp downstream of a TATA box sequence and 286 bp upstream of the translation initiation codon. The 3'-end of the mRNA was identified… CONTINUE READING

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