Structure and trafficking of NMDA and GABAA receptors.

@article{Stephenson2006StructureAT,
  title={Structure and trafficking of NMDA and GABAA receptors.},
  author={F Anne Stephenson},
  journal={Biochemical Society transactions},
  year={2006},
  volume={34 Pt 5},
  pages={
          877-81
        }
}
  • F. Stephenson
  • Published 1 October 2006
  • Biology
  • Biochemical Society transactions
The fidelity of synaptic function is dependent on the expression of the appropriate neurotransmitter receptor subtype, the targeting and trafficking of receptors to synapses as well as the regulation of the actual number of receptors at synapses. GABAA (gamma-aminobutyric acid type A) receptors and NMDA (N-methyl-D-aspartate) receptors are both examples of ligand-gated, heteromeric neurotransmitter receptors whose cell-surface expression is dynamic and tightly regulated. NMDA receptors are… 
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References

SHOWING 1-10 OF 24 REFERENCES
Regulation of GABAA receptor trafficking, channel activity, and functional plasticity of inhibitory synapses.
GABAA receptor cell surface number and subunit stability are regulated by the ubiquitin-like protein Plic-1
TLDR
A previously unknown role for Plic-1 is identified, a modulation of GABAA receptor cell surface number, which suggests that P lic-1 facilitates accumulation of these receptors in dendritic membranes.
Huntingtin-associated protein 1 regulates inhibitory synaptic transmission by modulating gamma-aminobutyric acid type A receptor membrane trafficking.
  • J. Kittler, P. Thomas, S. Moss
  • Biology
    Proceedings of the National Academy of Sciences of the United States of America
  • 2004
TLDR
A role for HAP1 is identified in regulating GABA(A)R sorting, suggesting an important role for this protein in the construction and maintenance of inhibitory synapses.
Excitatory glycine receptors containing the NR3 family of NMDA receptor subunits
TLDR
The cloning and characterization of the final member of the NMDAR family, NR3B, is reported, which shares high sequence homology with NR3A and is expressed predominantly in motor neurons, whereasNR3A is more widely distributed.
Structure and subunit composition of GABAA receptors
The γ2 Subunit of GABAA Receptors Is a Substrate for Palmitoylation by GODZ
TLDR
GODZ-mediated palmitoylation represents a novel posttranslational modification that is selective forγ subunit-containing GABAA receptor subtypes, a mechanism that is likely to be important for regulated trafficking of these receptors in the secretory pathway.
The role of receptor diffusion in the organization of the postsynaptic membrane
TLDR
This work focuses on the physical laws that govern receptor diffusion and stabilization, and how this might reshape how the authors think about the specific regulation of receptor accumulation at synapses.
Postsynaptic clustering of major GABAA receptor subtypes requires the γ2 subunit and gephyrin
TLDR
The γ2 subunit and gephyrin are interdependent components of the same synaptic complex that is critical for postsynaptic clustering of abundant subtypes of GABAA receptors in vivo.
GABAA Receptor-Associated Protein Regulates GABAA Receptor Cell-Surface Number in Xenopus laevis Oocytes
TLDR
GABARAP coexpression did not alter the general properties of GABAA receptors such as sensitivity to GABA or benzodiazepines, but it increased surface levels of receptor protein in oocytes, suggesting that it seems to supplement inadequate amounts of endogenous GABAR AP to support optimum trafficking and/or stabilization of surface GAB AA receptors.
The role of GABAA receptor biogenesis, structure and function in epilepsy.
TLDR
A number of recent studies on GABAA receptor mutations associated with epilepsy have further enhanced the understanding of GAB AA receptor biogenesis, structure and function.
...
1
2
3
...