Structure and synthesis of a potent glutamate receptor antagonist in wasp venom.

@article{Eldefrawi1988StructureAS,
  title={Structure and synthesis of a potent glutamate receptor antagonist in wasp venom.},
  author={Amira T. Eldefrawi and Mohyee E. Eldefrawi and Katsuhiro Konno and N. A. Mansour and Koji Nakanishi and Eugene M. Oltz and Peter N. R. Usherwood},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1988},
  volume={85 13},
  pages={4910-3}
}
A low molecular weight toxin isolated from the venom of the digger wasp Philanthus triangulum, first noted by T. Piek, is a potent antagonist of transmission at quisqualate-sensitive glutamate synapses of locust leg muscle. This philanthotoxin 433 (PTX-433) has been purified, chemically characterized, and subsequently synthesized along with two closely related analogues. It has a butyryl/tyrosyl/spermine sequence and a molecular weight of 435. Its two analogues, PTX-343 and PTX-334 (the… CONTINUE READING