Structure and substrate fingerprint of aminopeptidase P from Plasmodium falciparum.

  title={Structure and substrate fingerprint of aminopeptidase P from Plasmodium falciparum.},
  author={Nyssa Drinkwater and Komagal Kannan Sivaraman and Rebecca S. Bamert and Wioletta Rut and Khadija Mohamed and Natalie B. Vinh and Peter J. Scammells and Marcin Drąg and Sheena McGowan},
  journal={The Biochemical journal},
  volume={473 19},
Malaria is one of the world's most prevalent parasitic diseases, with over 200 million cases annually. Alarmingly, the spread of drug-resistant parasites threatens the effectiveness of current antimalarials and has made the development of novel therapeutic strategies a global health priority. Malaria parasites have a complicated lifecycle, involving an asymptomatic 'liver stage' and a symptomatic 'blood stage'. During the blood stage, the parasites utilise a proteolytic cascade to digest host… CONTINUE READING
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