Structure and regulatory mechanism of Aquifex aeolicus NtrC4: variability and evolution in bacterial transcriptional regulation.

@article{Batchelor2008StructureAR,
  title={Structure and regulatory mechanism of Aquifex aeolicus NtrC4: variability and evolution in bacterial transcriptional regulation.},
  author={Joseph D Batchelor and Michaeleen Doucleff and Chul-Jin Lee and Koshi Matsubara and Sacha De Carlo and Johanna Heideker and Meindert Hugo Lamers and Jeffrey G. Pelton and David E Wemmer},
  journal={Journal of molecular biology},
  year={2008},
  volume={384 5},
  pages={1058-75}
}
Genetic changes lead gradually to altered protein function, making deduction of the molecular basis for activity from a sequence difficult. Comparative studies provide insights into the functional consequences of specific changes. Here we present structural and biochemical studies of NtrC4, a sigma-54 activator from Aquifex aeolicus, and compare it with NtrC1 (a paralog) and NtrC (a homolog from Salmonella enterica) to provide insight into how a substantial change in regulatory mechanism may… CONTINUE READING

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