Structure and regulation of acetyl-CoA carboxylase genes of metazoa.

  title={Structure and regulation of acetyl-CoA carboxylase genes of metazoa.},
  author={Michael C Barber and Nigel T. Price and Maureen T Travers},
  journal={Biochimica et biophysica acta},
  volume={1733 1},
Acetyl-CoA carboxylase (ACC) plays a fundamental role in fatty acid metabolism. The reaction product, malonyl-CoA, is both an intermediate in the de novo synthesis of long-chain fatty acids and also a substrate for distinct fatty acyl-CoA elongation enzymes. In metazoans, which have evolved energy storage tissues to fuel locomotion and to survive periods of starvation, energy charge sensing at the level of the individual cell plays a role in fuel selection and metabolic orchestration between… CONTINUE READING


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