Structure and pharmacological properties of a molluscan glutamate-gated cation channel and its likely role in feeding behavior.

@article{Sthmer1996StructureAP,
  title={Structure and pharmacological properties of a molluscan glutamate-gated cation channel and its likely role in feeding behavior.},
  author={T St{\"u}hmer and Muriel Amar and Robert J Harvey and Isabel Bermudez and Jan van Minnen and Mark G. Darlison},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={1996},
  volume={16 9},
  pages={2869-80}
}
We describe the isolation of a molluscan (Lymnaea stagnalis) full-length complementary DNA that encodes a mature polypeptide (which we have named Lym-eGluR2) with a predicted molecular weight of 105 kDa that exhibits 44-48% identity to the mammalian kainate-selective glutamate receptor GluR5, GluR6, and GluR7 subunits. Injection of in vitro-transcribed RNA from this clone into Xenopus laevis oocytes results in the robust expression of homo-oligomeric cation channels that can be gated by L… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 16 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 73 references

domain topology for the glutamate receptor GluRl

  • ML Hutton, RJ Harvey, EA Barnard, MC Darlison
  • 1991
Highly Influential
4 Excerpts

Darlison MG (1994b) Sequence of a Drosophila ligand-gated ionchannel polypeptide with an unusual amino-terminal

  • ED Gundelfinger, H Betz
  • 1994

Molecular ChaI ’ XteriSdOn and functional expression of molluscan ion - channel receptors that can be activated by either y - aminobutyric acid or L - glutamate

  • MG Darlison, T Stiihmer, +5 authors J vanMinnen
  • Neth J Zoo
  • 1994

Physiological properties of neuronal nicotinic receptors reconstituted from the vertebrate / 32 subunit and Drosophila 01 subunits

  • D Bertrand, M Ballivet, M Gomez, S Bertrand, B Phannavong
  • Em J Neurosci
  • 1994

Similar Papers

Loading similar papers…