Structure and partial genomic sequence of the human E2F1 gene.

  title={Structure and partial genomic sequence of the human E2F1 gene.},
  author={Elizabeth Neuman and William R Sellers and John A McNeil and J B Lawrence and William G Kaelin},
  volume={173 2},
The E2F family of transcription factors appears to play a critical role in the transcription of certain genes required for cell cycle progression. E2F1, the first cloned member of this family, is regulated during the cell cycle at the mRNA level by changes in transcription of the E2F1 gene and at the protein level by complex formation with proteins such as the retinoblastoma gene product (pRB), cyclin A and DP1. E2F1 can override a pRB-induced G1/S block and can behave as an oncogene in certain… CONTINUE READING


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