Structure and mechanisms of lysine methylation recognition by the chromodomain in gene transcription.

@article{Yap2011StructureAM,
  title={Structure and mechanisms of lysine methylation recognition by the chromodomain in gene transcription.},
  author={Kyoko L. Yap and Ming-Ming Zhou},
  journal={Biochemistry},
  year={2011},
  volume={50 12},
  pages={1966-80}
}
Histone methylation recognition is accomplished by a number of evolutionarily conserved protein domains, including those belonging to the methylated lysine-binding Royal family of structural folds. One well-known member of the Royal family, the chromodomain, is found in the HP1/chromobox and CHD subfamilies of proteins, in addition to a small number of other proteins that are involved in chromatin remodeling and gene transcriptional silencing. Here we discuss the structure and function of the… CONTINUE READING

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