Structure and mechanism of the uracil transporter UraA

  title={Structure and mechanism of the uracil transporter UraA},
  author={Feiran Lu and Shuo Li and Yang Jiang and Jing Jiang and He Fan and Guifeng Lu and Dong Mei Deng and Shangyu Dang and Xu Sunny Zhang and Jiawei Wang and Nieng Yan},
The nucleobase/ascorbate transporter (NAT) proteins, also known as nucleobase/cation symporter 2 (NCS2) proteins, are responsible for the uptake of nucleobases in all kingdoms of life and for the transport of vitamin C in mammals. Despite functional characterization of the NAT family members in bacteria, fungi and mammals, detailed structural information remains unavailable. Here we report the crystal structure of a representative NAT protein, the Escherichia coli uracil/H+ symporter UraA, in… CONTINUE READING
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Molecular basis of alternating access membrane transport by the sodium-hydantoin transporter Mhp1

  • T Shimamura
  • Science 328,
  • 2010

Structure of a fucose transporter in an outward-open conformation

  • S Dang
  • Nature 467,
  • 2010

conservation mapping in 3D

  • L. Holm, Rosenström, P. Dali server
  • Nucleic Acids Res. 38, W545–W549
  • 2010

implication in the species difference in the intestinal absorption mechanism of nucleobases and their analogs between higher primates and other mammals

  • Yamamoto, S. et al. Identification, functional characterization of the first nucleobase transport mammals
  • J. Biol. Chem. 285, 6522–6531
  • 2010

Structure of a prokaryotic virtual proton pump at 3.2 Å resolution

  • Y Fang
  • Nature 460,
  • 2009

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