Structure and mechanism of the uracil transporter UraA

@article{Lu2011StructureAM,
  title={Structure and mechanism of the uracil transporter UraA},
  author={Feiran Lu and Shuo Li and Yang Jiang and Jing Jiang and He Fan and Guifeng Lu and Dong Mei Deng and Shangyu Dang and Xu Sunny Zhang and Jiawei Wang and Nieng Yan},
  journal={Nature},
  year={2011},
  volume={472},
  pages={243-246}
}
The nucleobase/ascorbate transporter (NAT) proteins, also known as nucleobase/cation symporter 2 (NCS2) proteins, are responsible for the uptake of nucleobases in all kingdoms of life and for the transport of vitamin C in mammals. Despite functional characterization of the NAT family members in bacteria, fungi and mammals, detailed structural information remains unavailable. Here we report the crystal structure of a representative NAT protein, the Escherichia coli uracil/H+ symporter UraA, in… CONTINUE READING
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