Structure and mechanism of the polynucleotide kinase component of the bacterial Pnkp-Hen1 RNA repair system.


Pnkp is the end-healing and end-sealing component of an RNA repair system present in diverse bacteria from many phyla. Pnkp is composed of three catalytic modules: an N-terminal polynucleotide 5'-kinase, a central 2',3' phosphatase, and a C-terminal ligase. Here we report the crystal structure of the kinase domain of Clostridium thermocellum Pnkp bound to… (More)
DOI: 10.1261/rna.036061.112


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