Structure and mechanism of the ATP synthase membrane motor inferred from quantitative integrative modeling

@inproceedings{Leone2016StructureAM,
  title={Structure and mechanism of the ATP synthase membrane motor inferred from quantitative integrative modeling},
  author={Vanessa Leone and Jos{\'e} D. Faraldo-G{\'o}mez},
  booktitle={The Journal of general physiology},
  year={2016}
}
Two subunits within the transmembrane domain of the ATP synthase-the c-ring and subunit a-energize the production of 90% of cellular ATP by transducing an electrochemical gradient of H+ or Na+ into rotational motion. The nature of this turbine-like energy conversion mechanism has been elusive for decades, owing to the lack of definitive structural information on subunit a or its c-ring interface. In a recent breakthrough, several structures of this complex were resolved by cryo-electron… CONTINUE READING
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