Structure and mechanism of mouse cyclase-associated protein (CAP1) in regulating actin dynamics.

@article{Jansen2014StructureAM,
  title={Structure and mechanism of mouse cyclase-associated protein (CAP1) in regulating actin dynamics.},
  author={Silvia Jansen and Agnieszka Collins and Leslie Golden and Olga S. Sokolova and Bruce L. Goode},
  journal={The Journal of biological chemistry},
  year={2014},
  volume={289 44},
  pages={30732-42}
}
Srv2/CAP is a conserved actin-binding protein with important roles in driving cellular actin dynamics in diverse animal, fungal, and plant species. However, there have been conflicting reports about whether the activities of Srv2/CAP are conserved, particularly between yeast and mammalian homologs. Yeast Srv2 has two distinct functions in actin turnover: its hexameric N-terminal-half enhances cofilin-mediated severing of filaments, while its C-terminal-half catalyzes dissociation of cofilin… CONTINUE READING
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The role of cyclase-associated protein in regulating actin Mammalian CAP1 Structure and Mechanism in Actin Regulation

  • S. Ono
  • OCTOBER 31,
  • 2013
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