Structure and mechanism of intramembrane protease.

  title={Structure and mechanism of intramembrane protease.},
  author={Ya Ha},
  journal={Seminars in cell & developmental biology},
  volume={20 2},
Many functionally important membrane proteins are cleaved within their transmembrane helices to become activated. This unusual reaction is catalyzed by a group of highly specialized and membrane-bound proteases. Here I briefly summarize current knowledge about their structure and mechanism, with a focus on the rhomboid family. It has now become clear that rhomboid protease can cleave substrates not only within transmembrane domains, but also in the solvent-exposed juxtamembrane region. This… CONTINUE READING

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