Structure and mechanism of human PrimPol, a DNA polymerase with primase activity

@inproceedings{Rechkoblit2016StructureAM,
  title={Structure and mechanism of human PrimPol, a DNA polymerase with primase activity},
  author={Olga Rechkoblit and Yogesh K Gupta and Radhika Malik and Kanagalaghatta R. Rajashankar and Robert E. Johnson and L. T. Om Prakash and Satya Prakash and Aneel K. Aggarwal},
  booktitle={Science Advances},
  year={2016}
}
PrimPol is a novel human enzyme that contains both DNA primase and DNA polymerase activities. We present the first structure of human PrimPol in ternary complex with a DNA template-primer and an incoming deoxynucleoside triphosphate (dNTP). The ability of PrimPol to function as a DNA primase stems from a simple but remarkable feature—almost complete lack of… CONTINUE READING

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