Structure and mechanism of cytosolic quinone reductases.

@article{Bianchet1999StructureAM,
  title={Structure and mechanism of cytosolic quinone reductases.},
  author={Mario A Bianchet and Christine E Foster and Margarita Faig and Paul Talalay and L. Mario Amzel},
  journal={Biochemical Society transactions},
  year={1999},
  volume={27 4},
  pages={
          610-5
        }
}
Introduction Quinones are ubiquitous dietary compounds. Reduction of quinones by one-electron reduction systems (cytochrome P450 reductases) results in the formation of reactive semiquinones that can be re-oxidized to quinones by molecular oxygen with the formation of superoxide radical (02-*). Superoxide can lead to the formation of other reactive oxygen species, including the highly mutagenic and carcinogenic hydroxyl radical. In addition, the presence of quinones and their one-electron… CONTINUE READING

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