Structure and mechanism of Na,K-ATPase: functional sites and their interactions.

@article{Jrgensen2003StructureAM,
  title={Structure and mechanism of Na,K-ATPase: functional sites and their interactions.},
  author={P. L. J{\o}rgensen and K. H{\aa}kansson and S. Karlish},
  journal={Annual review of physiology},
  year={2003},
  volume={65},
  pages={
          817-49
        }
}
The cell membrane Na,K-ATPase is a member of the P-type family of active cation transport proteins. Recently the molecular structure of the related sarcoplasmic reticulum Ca-ATPase in an E1 conformation has been determined at 2.6 A resolution. Furthermore, theoretical models of the Ca-ATPase in E2 conformations are available. As a result of these developments, these structural data have allowed construction of homology models that address the central questions of mechanism of active cation… Expand
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